| Publication Type: | Journal Article |
| Year of Publication: | 1999 |
| Authors: | A. Meister, Bernhardt, G., Christoffel, V., Buschauer, A. |
| Journal: | Planta Medica |
| Volume: | 65 |
| Issue: | 6 |
| Pagination: | 512 - 516 |
| Date Published: | 1999/08// |
| Abstract: | The effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F-2 alpha). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F-2 alpha being most efficiently antagonized. |
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