Publication Type: | Journal Article |
Year of Publication: | 1996 |
Authors: | H. Haraguchi, Saito, T., Ishikawa, H., Date, H., Kataoka, S., Tamura, Y., Mizutani, K. |
Journal: | Planta Medica |
Volume: | 62 |
Issue: | 3 |
Pagination: | 217 - 221 |
Date Published: | 1996/06// |
Abstract: | A biphenyl compound, 3,4,3',4'-tetrahydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1), and a flavonoid, eriodicytol (2), were isolated as antioxidative components from the leaves of Thymus vulgaris by bioassay-directed fractionation. These compounds inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited by these compounds. Compound 1 is an extremely potent antioxidant; complete inhibition was observed at 1 mu M against both microsomal and mitochondrial peroxidation. Furthermore, compound 1 protected red cells against oxidative hemolysis. These phenolic compounds were shown to be effective to protect biological systems against various oxidative stresses. |
Antiperoxidative components in Thymus vulgaris
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