02281nas a2200205   4500008004100000020001400041245011400055210006900169260011500238300001400353490000600367520132500373100002201698700002001720700001801740700002001758700002001778700002201798856025501820       2003                        eng d  a1672-197700aOriginal studies on anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak in mice0 aOriginal studies on antitumor and immunological effect of extrac  aAffiliation: Department of Biology, Liaocheng University, Liaocheng, Shandong Province 252059, China.c2003///  a209 - 2100 v13 aOBJECTIVE: To study the anti-tumor and immunological effect of extracts from Thymus quinquecostatus Celak on mice transplanted S180 tumor cells. METHODS: Different doses of volatile oil and alcohol extracted substances from Thymus quinquecostatus Celak were given to mice bearing S180 tumor for 9 days. Tumor inhibition rates and coefficients of spleen and thymus were determined. RESULTS: Tumor inhibition rates of the groups with alcohol extracts (40 g crude drug.kg(-1).d(-1) and 20 g crude drug.kg(-1).d(-1)) were 51.5% (P<0.01) and 36.4% (P<0.05) respectively, and those of the groups with volatile oil (40 g crude drug.kg(-1).d(-1) and 20 g crude drug.kg(-1).d(-1))were both 39.4% (P<0.05). CONCLUSION: The extracts from Thymus quinquecostatus Celak have anti-tumor activities. The coefficient of spleen in group with alcohol extracts (40 g crude drug.kg(-1).d(-1))was close to normal value, and its coefficient of thymus was between that of the negative control group and the group with cyclophosphamide (0.02 g.kg(-1).d(-1)). The anti-tumor activity of the alcohol extracts was significantly higher than that of the control group and the tumor inhibition rate was depending on drug concentration. Depending on index of immunity,the extracts from Thymus quinquecostatus Celak may have some influences on immunity.1 aSun, Zhen-Xiao, X1 aSun, Jin-Hua, H1 aCheng, Shuang1 aMa, Qing-Wen, W1 aGuo, Shan-Li, L1 aZhang, Jin-Bao, B  uhttp://muse.lib.auth.gr:9797/com/csa/?MuseHost=www-mi2.csa.com&MuseFirst=1&id=2&recnum=4&SID=b8599c660c0d7abb640bacacd8dd54da&MusePath=/ids70/view_record.phphttp://www.scopus.com/scopus/inward/record.url?eid=2-s2.0-16644369614&partnerID=40&rel=R6.5.0