01265nas a2200169   4500008004100000245013800041210006900179260001400248300001400262490000700276520061600283100001500899700001700914700001900931700001700950856012800967       1999                        eng d00aAntispasmodic activity of Thymus vulgaris extract on the isolated guinea-pig trachea: Discrimination between drug and ethanol effects0 aAntispasmodic activity of Thymus vulgaris extract on the isolate  c1999/08//  a512 - 5160 v653 aThe effect of an extract of Thymus vulgaris on induced spasms was investigated on guinea-pig trachea preparations. By the experimental setup used, effects of ethanol as the vehicle could be differentiated from the activity of the herbal constituents. The extract reversibly and concentration-dependently antagonized the contraction of the Musculus transversus tracheae, provoked by four different spasmogens (BaCl2, carbachol, histamine, prostaglandin F-2 alpha). The degree of the antispasmodic activity was dependent on the individual spasmogen with prostaglandin F-2 alpha being most efficiently antagonized.1 aMeister, A1 aBernhardt, G1 aChristoffel, V1 aBuschauer, A  uhttps://thymus.myspecies.info/ref/antispasmodic-activity-thymus-vulgaris-extract-isolated-guinea-pig-trachea-discrimination